Insulin and growth hormone-releasing peptide-6 (GHRP-6) have differential beneficial effects on cell turnover in the pituitary, hypothalamus and cerebellum of streptozotocin (STZ)-induced diabetic rats
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منابع مشابه
Use of growth-hormone-releasing peptide-6 (GHRP-6) for the prevention of multiple organ failure.
Novel therapies for the treatment of MOF (multiple organ failure) are required. In the present study, we examined the effect of synthetic GHRP-6 (growth hormone-releasing peptide-6) on cell migration and proliferation using rat intestinal epithelial (IEC-6) and human colonic cancer (HT29) cells as in vitro models of injury. In addition, we examined its efficacy when given alone and in combinati...
متن کاملstudy the effects of low level laser diode on no production and healing of diabetic and cortisone acetate and normal wounded sd rats
nitric oxide (no) is a small molecule synthesized by most of mammalian cells with diverse biological activities including vasodilatation, host defense and wound healing. impaired wound healing is a common occurrence among diabetics and patients receiving glucocorticoid therapy. on the other hand the application of laser in biomedical area have been increased. thus, the current studies were desi...
15 صفحه اولBravo 6 Effect of thyrotropin releasing hormone ( TRH ) on insulin secretion in the neonatally streptozotocin ( STZ ) injected diabetic rat
TRH is synthesized in insulin secreting pancreatic B cells and its level here culminates during neonatal period. Neonatal STZ (nSTZ) treatment results in parallel depletion of both insulin and TRH in the rat pancreas. In contrast to the insulin, destruction of pancreatic TRH system was reported to be irreversible. A disturbance of insulin response to glucose stimulation similar to that observed...
متن کاملPituitary growth hormone secretory granules in streptozotocin-induced diabetic rats.
The ultrastructural features of growth hormone (GH) secretory granules were observed by immuno-gold procedure in the anterior pituitary glands of streptozotocin (STZ)-induced diabetic rats. The diabetic state of rats induced by one injection of STZ was severely advanced at 10 months after the injection. The cytoplasmic organella were revealed to be poorly developed in GH-cells of the diabetic r...
متن کاملThe effects of crocin, insulin and their co-administration on the heart function and pathology in streptozotocin-induced diabetic rats
Objective: Crocinisa saffron constituent with a potent anti-oxidant activity. The present study investigated the effects of crocin and insulin treatments (alone or in combination) on cardiac function and pathology in diabetic rats. Materials and Methods: Diabetes was induced by intraperitoneal (i.p.) injection of streptozotocin (STZ, 50 mg/kg). Thereafter, crocin (5, 10 and 20 mg/kg, i.p.), sub...
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ژورنال
عنوان ژورنال: Molecular and Cellular Endocrinology
سال: 2011
ISSN: 0303-7207
DOI: 10.1016/j.mce.2011.02.002